RNA Details
Disease Name
cardiomegaly
Tissue
heart
RNA Symbol
mir-1
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
rattus norvegicus
Detection Methods
dual-luciferase reporter assay
Target
TWINFILIN-1
Pathway
NA
PubMed ID
Title
Attenuation of microRNA-1 derepresses the cytoskeleton regulatory protein twinfilin-1 to provoke cardiac hypertrophy
Year
2010
Function
"Reduction of miR-1 by hypertrophic stimuli induces the upregulation of twinfilin-1, which in turn evokes hypertrophy through the regulation of cardiac cytoskeleton."